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    Chemical Biology Team

    RIKEN Center for Biosystems Dynamics Research (BDR)

　

HOT PAPER

“Copper-Catalyzed Regioselective Monofluoroborylation

  of Polyfluoroalkenes en Route to Diverse Fluoroalkenes”

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Hironobu Sakaguchi, Yuta Uetake, Masato Ohashi, Takashi Niwa*,

Sensuke Ogoshi*, Takamitsu Hosoya* (H.S. and Y.U. contributed equally.)

J. Am. Chem. Soc. 2017, 139, 12855–12862.

DOI:10.1021/jacs.7b08343

“A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation”

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Makoto Hatakeyama,* Yuki Sakamoto, Koji Ogata, Yuto Sumida, Tomoe Sumida, Takamitsu Hosoya, Shinichiro Nakamura*

Phys. Chem. Chem. Phys. 2017, 19, 26926–26933.

DOI:10.1039/c7cp04739h

“Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides” (invited paper)

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Yuto Sumida*, Tomoe Sumida, Takamitsu Hosoya*

Synthesis 2017, Special Topic in press.

DOI: 1055/s-0036-15884649

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“Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-Catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters”

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Takashi Niwa,* Hidenori Ochiai, Motoyuki Isoda, Takamitsu Hosoya*

Chem. Lett. 2017, in press.

DOI:10.1246/cl.170549

“Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids”

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Hidenori Ochiai, Yuta Uetake, Takashi Niwa*, Takamitsu Hosoya*

Angew. Chem., Int. Ed. 2017, 56, 2482–2486.

DOI: 10.1002/anie.201611974.

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ABOUT US

Aim of this team is to develop world’s first innovative chemistries that contribute to the promotion of human live science and drug discovery.

 

Major research interests of the team include development of

1. Novel strategies for efficient PET probe synthesis,

2. Useful PET probes for in vivo imaging of target molecules,

3. Chemical tools and methods that facilitate chemical biology researches, and

4. Efficient synthetic methods for valuable compounds that are difficult to obtain by the conventional approaches.

 

To achieve these goals, chemists from a variety of fields, including medicinal chemistry and organometallic chemistry, are engaged in this team. Through the promotion of the researches under collaboration with a number of scientists of different disciplines inside and outside the center, we are looking to face with significant challenges, which need to be addressed by the chemical innovations.

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