論　文　リ　ス　ト （2014年4月16日現在）

張 周恩(Zhouen Zhang)

 

PUBLICATIONS:

 

15.　

Pd0-Mediated Rapid Cross-Coupling Reactions, the Rapid C-[11C]Methylations, Revolutionarily Advancing the Synthesis of Short-Lived PET Molecular Probes.

Masaaki Suzuki, Hisashi Doi, Hiroko Koyama, Zhouen Zhang, Takamitsu Hosoya, Hirotaka Onoe, Yasuyoshi Watanabe.

The Chemical Record, 2014, 14: 516–541.

DOI: 10.1002/tcr.201400002

 

 

 

14.　

Efficient Syntheses of [11C]Zidovudine and its Analogues by Convenient One-pot Palladium(0)-Copper(I) Co-mediated Rapid C-[11C]Methylation;.

Zhouen Zhang, Hisashi Doi, Hiroko Koyama, Yasuyoshi Watanabe, Masaaki Suzuki;

Labelled Compounds and Radiopharmaceuticals, 2014, 57: 540–549.　

DOI: 10.1002/jlcr.3213

 

 

 

13.　

Pd0-Mediated Rapid Coupling of Methyl Iodide with Excess Amounts of Benzyl- and Cinnamylboronic Acid Esters: Efficient Method for Incorporation of Positron–Emitting 11C Radionuclide into Organic Frameworks by Coupling between Two sp3-Hybridized Carbons.

Hiroko Koyama, Zhouen Zhang, Ryosuke Ijuin, Siqin, Jeongwan Son, Yuma Hatta, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi, Masaaki Suzuki.

RSC Advances, 2013, 3: 9391–9401.　

DOI: 10.1039/C3RA40815A

 

 

 

12.　

Highly efficient syntheses of [methyl-11C]thymidine and its analogue 4’-[methyl-11C]thiothymidine as nucleoside PET probes for cancer cell proliferation by Pd0-mediated rapid C-[11C] methylation.

Hiroko Koyama, Siqin, Zhouen Zhang, Kengo Sumi, Yuma Hatta, Hiroko Nagata, Hisashi Doi, Masaaki Suzuki.

Organic & Biomolecular Chemistry, 2011, 9: 4287-4294.

DOI: 10.1039/C0OB01249A

 

 

 

11.　

Development of Novel Oxygen-independent Photosensitizers.

Zhouen Zhang, Ken-ichi Haruna, Takeo Ito, Hiroshi Hatta, Sei-ich Nishimoto.

Nucleic Acid Symposium Series 2007, 51. 229-230.

DOI: 10.1093/nass/nrm115

 

 

 

10.　

Current Molecular Design of Intelligent Drugs and Imaging Probes Targeting Tumor-Specific Microenvironments.

Kazuhito Tanabe, Zhouen Zhang, Takeo Ito, Hiroshi Hatta, Sei-ichi Nishimoto.

Organic & Biomolecular Chemistry, 2007, 5, 3745-3757. 

DOI: 10.1039/B711244K

 

 

9. 　

Molecular design of a new class of hypoxic tumor-cell targeting antitumor prodrugs.

Sei-ichi Nishimoto, Zhouen Zhang, Kazuhito Tanabe, Takeo Ito, Hiroshi Hatta.

Japanese Journal of Cancer Clinics, 2006, 52, 1-9

 

 

 

8.　

A New Class of 5-Fluoro-2’-deoxyuridine Prodrugs Conjugated With a Tumor Homing Cyclic Peptide CNGRC by Ester Linkers: Synthesis, Reactivity and Tumor-Cell Selective Cytotoxicity. 

Zhouen Zhang, Hiroshi Hatta, Kazuhito Tanabe, Sei-ichi Nishimoto.

Pharmaceutical Research, 2005, 22, 381-389.

DOI: 10.1007/s11095-004-1875-x

 

 

 

7. 　

Aminopeptidase N/CD13 Targeting Fluorescent Probes: Design, Synthesis and Application to Tumor Cell Imaging.

Zhouen Zhang, Hiroshi Harada, Kazuhito Tanabe, Hiroshi Hatta, Masahiro Hiraoka, Sei-ich Nishimoto.

Peptides, 2005, 26, 2182-2187. 

DOI: 10.1016/j.peptides.2005.03.049

 

 

 

6. 　

Bioreduction Activated Prodrugs of Camptothecin: Molecular Design, Synthesis, Activition Mechanism and Hypoxia Selective Cytotoxicity. 

Zhouen Zhang, Kazuhito Tanabe, Hiroshi Hatta, Sei-ich Nishimoto. 

Organic & Biomolecular Chemistry, 2005, 3, 1905-1910. 

DOI: 10.1016/j.peptides.2005.03.049

 

 

 

5. 　

Synthesis and Photochemical Properties of Photoactivated Antitumor Prodrugs Releasing 5-Fluorouracil. 

Zhouen Zhang, Hiroshi Hatta, Takeo Ito, Sei-ichi Nishimoto.

Organic & Biomolecular Chemistry, 2005, 3, 592-596. 

DOI: 10.1039/B417734G

 

 

 

4. 　

Oxidation of Guanine and Guanosine by Nitrogen Dioxide Radical at Basic pH.

Zhouen Zhang, Side Yao, Yinzun Jin, Nianyun Lin. 

Journal of Radiation Research and Radiation Processing, 2001, 19, 148-152.

 

 

 

3. 　

Condensation of meldrum acid with carbonyl compounds in dry media under microwave irradiation.

Li-xue Zhang, Zhouen Zhang, Gaozhong Cao.

Hecheng Huaxue, 1998, 6, 235-237.

 

 

 

2.　

Kinetic Confirmation of The Scavenging　Reaction of Ferulic Acid and Sinapic Acid With Nitrogen Dioxide Radical.

Zhouen Zhang, Side Yao, Wenfen Wang, Nianyun Lin.

Huanjing Kexue Xuebao, 1998, 18, 396-400. 

 

 

 

1. 　

Mechanism of Reaction of Nitrogen Dioxide Radical with Hydroxycinnamic Acid Derivatives: A Pulse Radiolysis Study.

Zhouen Zhang, Side Yao, Weizhen Lin, Nianyun Lin.

Free Radical Research, 1998, 29, 13-16.

 

 

 

PATENTS:

 

1.　西本清一、張周恩；標的部位で選択的に活性化される新規化合物およびその利用；日本国特願:2005-067728

２．西本清一、張周恩；新規光感受性化合物およびその利用；日本国特願:2005-067710

３．西本清一、張周恩、田邉一仁；標的部位で選択的に活性化される新規化合物およびその利用；日本国特願:2005-359434

4. Sei-ichi Nishimoto, Zhouen Zhang, Kazuhito Tanabe; Preparation of Camptothecin Derivatives for Target Therapy and D　iagnostic Imaging. PCT Int. Appl. 2006, WO 2006095636.

5.  鈴木正昭、張周恩、田原強、尾上浩隆、土居久志； [11C]標識ジドブジン、それを用いたＰＥＴ用プローブ及び癌イメージング法；日本国特願、2013-90343.